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Their findings, posted recently within the journal Neuron, concentrate on M4, a subtype from the muscarinic acetylcholine category of nerve cell receptors activated by binding the neurotransmitter acetylcholine. The Vanderbilt scientists discovered that M4 neurons project in to the substantia nigra pars reticulata, a little structure close to the foot of the mind important in regulating motion. Right here M4 receptor activation opposes signaling by another course of receptors that binds the neurotransmitter dopamine. When, in Parkinson’s disease, dopamine-producing neurons commence to perish off, the opposing actions of M4 neurons can suppress dopamine signaling even more.